HIGH INTENSITY INTERVAL TRAINING FAVOURABLY AFFECTS ANTIOXIDANT AND INFLAMMATION mRNA EXPRESSION IN
O nosso núcleo de pesquisa promove reuniões científicas semanais. Nelas, cada integrante apresenta artigo relacionado com o tema de nosso projeto.
Fiquei responsável pelo artigo HIGH INTENSITY INTERVAL TRAINING FAVOURABLY AFFECTS ANTIOXIDANT AND INFLAMMATION mRNA EXPRESSION IN EARLY-STAGE KIDNEY DISEASE. Abaixo está minha apresentação (basta passar para o lado) e o resumo do artigo.
Increased levels of oxidative stress and inflammation have been linked to the progression of chronic kidney disease. To reduce oxidative stress and inflammation related to chronic kidney disease, chronic aerobic exercise is often recommended. Data suggests high intensity interval training may be more beneficial than traditional aerobic exercise. However, appraisals of differing modes of exercise, along with explanations of mechanisms responsible for observed effects, are lacking. This study assessed effects of eight weeks of high intensity interval training (85% VO2max), versus low intensity exercise (45-50% VO2max) and sedentary behaviour, in an animal model of early-stage chronic kidney disease. We examined kidney-specific mRNA expression of genes related to endogenous antioxidant enzymeactivity (glutathione peroxidase 1; Gpx1, superoxide dismutase 1; Sod1, and catalase; Cat) and inflammation (kidney injury molecule 1; Kim1 and tumour necrosis factor receptor super family 1b; Tnfrsf1b), as well as plasma F2-isoprostanes, a marker of lipid peroxidation. Compared to sedentary behaviour, high intensity interval training resulted in increased mRNA expression of Sod1 (p=0.01) and Cat (p<0.001). Compared to low intensity exercise, high intensity interval training resulted in increased mRNA expression of Cat (p<0.001) and Tnfrsf1b (p=0.047). In this study, high intensity interval training was superior to sedentary behaviour and low intensity exercise as high intensity interval training beneficially influenced expression of genes related to endogenous antioxidant enzyme activity and inflammation.
Considero as reuniões como de extrema valia para o crescimento intelectual, uma vez que desse modo temos acesso a uma vasta literatura científica. Ademais, também nos possibilita uma análise crítica do material encontrado, além das discussões após as apresentações criarem uma arguição mais intensa e que promove a fixação melhor do conhecimento.
